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	Like a few other Deep Space Nine episodes, the final title works equally well for both the A and B stories (Rio Grande means Great River, referring to the Great Material Continuum; treachery refers to Weyoun 6's defection, and faith to his loyalty to Odo.)
	The Female Changeling begins to exhibit the effects of the morphogenic virus in this episode. The virus was created by Section 31, who infected Odo with it in the fourth season episode "Homefront". Odo in turn infected the Great Link in the season 4 finale "Broken Link". Presumably, he was also "cured" of the virus in that episode when he was made a solid. He was subsequently re-infected by the Female Changeling in the sixth season episode "Behind the Lines", which explains why Odo and Weyoun believe that Odo is in fact free of the disease even though other Founders have begun to exhibit symptoms, as well as why Odo, who was initially infected long before any other Founder, was the last to exhibit symptoms.
	It's possible that Gul Russol is the contact to whom Odo speaks in "Improbable Cause"; he mentions that Russol was one of his most reliable contacts, and in "Improbable Cause", he obviously places great faith in his informant, so there is a possibility that they are one and the same.
	This is the first episode in which Damar expresses a strong sense of patriotism, mentioning all that Cardassia has lost in the Dominion War. This would go on to be a major factor in his character turning against the Dominion in the ten-hour, nine episode arc which closes the series.
	On the runabout, Weyoun was trying to eat a pepperoni pizza with chopsticks.
	The B-story of this episode recalls both the first season episode "Progress" and the fifth season episode "In the Cards" insofar as Nog is trying to acquire something specific, but keeps getting other items in an attempt to work his way back to what he originally wanted.
	Referenced Rules of Acquisition: #168 ("Whisper your way to success")
	It is not clear why air and an appropriate temperature are needed to keep Odo alive; since he does not eat, he presumably has no metabolism that would need oxygen as a fuel and temperature as a catalyst. "Chimera" also sees another changeling having no problem with at least changing into something that can live in space.
	This is the first of two times after the discovery of the Dominion that Odo is referred to as a "shapeshifter" instead of a Changeling; Damar uses this term when talking to Odo. Odo himself would later use it in "Chimera".
	This was the first named appearance of the Rio Grande since "The Ascent", finally confirming that the ship was salvaged and repaired.

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